NephrologyOnline.net

Nephrology Xagena

Idiopathic membranous nephropathy is an autoimmune disease. In approximately 70% of patients, it is associated with autoantibodies against the phospholipase A2 receptor 1 ( PLA2R1 ). Antigenic targets ...


Hypertension is common in autosomal dominant polycystic kidney disease ( ADPKD ) and is associated with increased total kidney volume, activation of the renin–angiotensin–aldosterone system, and progr ...


Oral anticoagulation therapy ( OAT ) is the choice treatment for thromboembolism prevention in atrial fibrillation ( AF ), although data about oral anticoagulants use in haemodialysis ( HD ) patients ...


Abnormal mineral metabolism is a hallmark in patients with advanced chronic kidney disease ( CKD ). Hyperphosphatemia, and the homeostatic mechanisms controlling phosphate metabolism, have received pa ...


Fibroblast growth factor 23 ( FGF23 ) and Klotho are associated with vascular calcification and cardiovascular disease in dialysis patients. Sevelamer ( Renagel, Renvela ) has been shown to reduce p ...


Serum Alkaline phosphatase ( ALP ) & phosphate are considered to be indicators of vascular calcification. Link between bone metabolism, vascular calcification, cardiovascular events have been well ...


A study has assessed the effects and safety of iron-based phosphate binders in adult patients receiving dialysis. Eight studies with 2018 participants were eligible for the meta-analysis. Iron- ...


The concept of chronic kidney disease - mineral bone disorder ( CKD-MBD ) does not appear to fulfil the requirements for a syndrome at first glance, but its definition has brought some clear-cut benef ...


Reduction of dietary sodium intake or diuretic treatment increases renin-angiotensin-aldosterone system ( RAAS ) blockade efficacy in non-diabetic nephropathy. A study has investigated the effect of ...


Risk of end-stage renal disease ( ESRD ) in kidney donors has been compared with risk faced by the general population, but the general population represents an unscreened, high-risk comparator. A co ...


Peritoneal dialysis is the renal replacement therapy of choice for acute kidney injury in neonates, but in some cases is not feasible or effective. Continuous renal replacement therapy ( CRRT ) machin ...


The two largest studies of mammalian target of rapamycin inhibitor treatment of autosomal dominant polycystic kidney disease ( ADPKD ) have demonstrated no clear benefit on the primary endpoint of tot ...


In phase 4 IMPACT-SHPT study, efficacy and safety of Paricalcitol-centred therapy were compared with that of Cinacalcet-centred therapy for the treatment of chronic kidney disease (CKD)-associated sec ...


In autosomal dominant polycystic kidney disease ( ADPKD ), progressive kidney cyst formation commonly leads to end-stage renal disease ( ESRD ). Because important manifestations of ADPKD may be evid ...


The role of hyperuricemia in disease progression of autosomal dominant polycystic kidney disease ( ADPKD ) has not been defined well. Researchers have investigated the association of serum uric acid ...


Autosomal dominant polycystic kidney disease ( ADPKD ) is a major cause of end-stage kidney failure, but is often identified early and therefore amenable to timely treatment. Interventions known to ...


New-onset diabetes after transplantation ( NODAT ) is a common complication after renal transplantation. There are limited available oral drugs to treat hyperglycaemia in this population owing to redu ...


Atherosclerotic renal-artery stenosis is a common problem in the elderly. Despite two randomized trials that did not show a benefit of renal-artery stenting with respect to kidney function, the useful ...


Abdominal aortic calcification ( AAC ) is reported as a predictor for cardiovascular events in general population and in hemodialysis patients. At present, there are no AAC data in peritoneal dialysis ...


Hyperphosphataemia is a known independent risk factor for cardiovascular mortality. The objective of the study was to compare the effects of two phosphate binders, Sevelamer carbonate ( Renvela ) and ...


Tolvaptan ( Samsca ), a diuretic with a new mechanism of action, selectively binds to the vasopressin V2 receptor and inhibits reabsorption of water. Its effect on heart failure is proven, but its ben ...


Tolvaptan ( Samsca ), a diuretic with a new mechanism of action, selectively binds to the vasopressin V2 receptor and inhibits reabsorption of water. Its effect on heart failure is proven, but its ben ...


Endothelial dysfunction underlies multiple cardiovascular consequences of chronic kidney disease ( CKD ) and antecedent diabetes or hypertension. Endothelial insults in chronic kidney disease or end-s ...


Contrast-induced nephropathy ( CIN ) is a frequent complication of many radiological procedures involving the application of contrast media. It represents a significant health problem that causes the ...


Membranous nephropathy leads to end-stage renal disease in more than 20% of patients. Although immunosuppressive therapy benefits some patients, trial evidence for the subset of patients with declinin ...


Combination therapy with angiotensin-converting–enzyme ( ACE ) inhibitors and angiotensin-receptor blockers ( ARBs, sartans ) decreases proteinuria; however, its safety and effect on the progression o ...


Levels of a protein in the urine of kidney transplant recipients can distinguish those at low risk of developing kidney injury from those at high risk. The results also suggest that low levels of this ...


Results from the FIND-CKD study were presented at the American Society of Nephrology ( ASN ) Kidney Week in Atlanta, Georgia, USA. The FIND-CKD results have shown that Ferinject ( Ferric carboxymaltos ...


Vasopressin V2-receptor antagonists may delay disease progression in autosomal dominant polycystic kidney disease ( ADPKD ). Trials with V2-receptor antagonists have been performed predominantly i ...


Peginesatide, a synthetic peptide-based erythropoiesis-stimulating agent ( ESA ), is a potential therapy for anemia in patients with advanced chronic kidney disease.Researchers have conducted two rand ...


The FDA ( Food and Drug Administration ) has advised healthcare professionals of significant liver injury associated with the use of Samsca ( Tolvaptan ). In a double-blind, 3-year, placebo-controlled ...


Individuals with the autoimmune disease systemic lupus erythematosus ( SLE ) can experience a number of medical complications, such as lupus nephritis, an inflammatory kidney disorder. Lupus affec ...


Vasopressin antagonists increase the serum sodium concentration in patients who have euvolemia and hypervolemia with hyponatremia in the short term ( less than or equal to 30 days ), but their safety ...


Pregnancy after kidney transplant has become possible thanks to the recent surgical and pharmacological breakthrough. Researchers have performed a retrospective study including all childbearing wom ...


Treatment with Rituximab can significantly benefit some patients with severe lupus nephritis who do not respond to conventional therapy, according to a study published in the Clinical Journal of the ...


Freezing kidney tumors should be the gold standard or first treatment option for all individuals with tumors that are 4 centimeters in size or smaller. And, this treatment, interventional cryoablati ...


The drug Rituximab causes considerable kidney injury healing in patients with membranous nephropathy, a common form of kidney disease, according to a study appearing in the November 2008 issue of th ...


Large, for-profit dialysis facilities appear to administer higher than necessary amounts of a medication for treating anemia in patients with kidney disease, compared to nonprofit facilities, accord ...


Post-operative kidney cancer patients show no increased recurrence-free survival ( RFS ) when given the new vitespen vaccine. However a possible improvement in RFS in patients with early stage disea ...


Since sunitinib malate has shown activity in two uncontrolled studies in patients with metastatic renal-cell carcinoma, a comparison of the drug with interferon alfa in a phase 3 trial is warrante ...


A three-year multi-center study of kidney-pancreas transplant recipients has identified a new risk factor for impaired kidney function, which may help physicians refine their treatment strategies. ...


Researchers at the University of Michigan Comprehensive Cancer Center found that a less aggressive type of surgery designed to spare healthy organ tissue is used infrequently to treat early-stage kidn ...


Researchers at the University of California, San Francisco ( UCSF ) have determined that there is a strong relationship between being obese and developing end-stage renal disease, or kidney failure. ...


In a study, published in the American Journal of Hypertension, researchers at the University of Michigan ( U-M ) have reported that blood pressure was higher, and more likely to rise with age, among p ...


Night-time hemodialysis patients may have a greater capacity to repair their hearts and blood vessels compared to those on conventional dialysis three times a week, according to a study in the America ...


Patients with type 1 diabetes have an improved prognosis with regard to end-stage renal disease over the past four decades, and it appears the incidence of end-stage renal disease is lower than previo ...


People who receive a kidney transplant are nearly four times more likely to develop melanoma, a rare but deadly form of skin cancer. The study, published in the journal Cancer, indicates that risk ...


Researchers at Mayo Clinic searching for explanations of high mortality rates among kidney failure patients undergoing hemodialysis are focusing their attention on the use of Heparin, a drug used to r ...


A Mayo Clinic study found men who experience signs and symptoms of a prostate obstruction resulting from benign prostatic hyperplasia ( BPH ) are three times more likely than other men to develop chr ...


A study by researchers at the Johns Hopkins Bloomberg School of Public Health and other institutions, found two common gene variations are associated with the risk for developing chronic kidney disea ...



2000-2014© XAGENA srl - P.IVA: 04454930969 - REA: 1748680 - Tutti i diritti riservati